Fig. 1

Endothelin-1 is elevated in aqueous humor in the normal tension and primary open angle glaucoma cohorts. Graph showing measurements of endothelin-1 (ET-1) concentration in aqueous humor from patients across three glaucoma cohorts, including normal tension glaucoma (NTG), primary open angle glaucoma (POAG), and exfoliative glaucoma (XFG) and a normal control cohort. Statistically higher concentrations of ET-1 were detected in aqueous humor samples from POAG (n = 25, p = 0.002) and NTG (n = 17, p = 0.030) compared to controls (n = 12). Despite a trend for higher concentrations of ET-1 in aqueous humor from patients in the XFG cohorts (n = 8, p = 0.15) relative to controls, this did not reach statistical significance. In this graph, each bar represents mean ET-1 concentration ± standard deviation, each dot represents data from one sample per patient within each cohort, and statistical analysis with inset p-values (calculated using a two-tailed Welch’s t-Test without correction for multiple comparisons).