Fig. 1

A shows the various layers of the macula in a preterm infant with ROP (zone II, stage 1, GA = 29.43w, BW = 1645 g, PMA = 36.43w), while B shows the layers of the macula in a healthy adult: Nerve Fiber, Ganglion Cell, Inner Plexiform, Inner Plexiform, Outer Plexiform, Outer Nuclear, external limiting membranes (ELM), Ellipsoid Zone (EZ), Interdigitation Zone (IZ), and RPE. FD is the distance from the lowest point of the fovea to the apex of the line between the highest points of the nasal and temporal fovea (white line). CFT was defined as the thickness of the entire retina from the inner aspect of the ILM to the inner aspect of the retinal RPE at the foveal center (Blue line plus red line). PT was the mean of the temporal and nasal-lateral retinal thickness 1000 μm from the foveal center (the mean of the two green lines plus the two yellow lines). FIRL included all retinal tissue from the inner aspect of the ILM to the outer border of the INL in the foveal center (blue line). FORL was measured from the outer border of the INL to the inner border of the RPE in the foveal center (red line). PIRL was the mean of the temporal and nasal-lateral inner retinal layer thickness at 1000 μm from the foveal center (the mean of the two green lines). PORL was the mean of the temporal and nasal-lateral outer retinal layer thickness at 1000 μm from the foveal center (the mean of the two yellow lines). FA was measured at the lowest point of the fovea and at the parafoveal points on either side where the retinal contour started to flatten, indicated by the angle between two slanted purple lines