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Table 1 Demographics and clinical characteristics of the study subjects

From: Comparative analysis of the optic nerve microvasculature between different optic disc phenotypes of normal-tension glaucoma patients

 

A: Healthy group

(n = 50)

B: Focal

ischemic group

(n = 50)

C: Myopic

glaucomatous group

(n = 50)

P value

(A vs. B, A vs. C, B vs. C)

Age (year)

56.2 ± 9.8

58.5 ± 9.8

55.2 ± 9.3

0.229

Sex (M/F)

23/27

25/25

22/28

0.829†

SBP (mmHg)

122.7 ± 16.4

125.9 ± 14.3

121.7 ± 14.5

0.466

DBP (mmHg)

73.7 ± 11.1

76.6 ± 8.3

74.8 ± 8.2

0.422

MOPP (mmHg)

49.3 ± 7.6

52.4 ± 6.2

49.5 ± 6.5

0.113

AL (mm)

24.6 ± 1.3

24.4 ± 1.3

25.7 ± 1.0

< 0.001

(0.443, < 0.001, < 0.001)

SE (diopter)

-1.9 ± 2.7

-1.0 ± 2.3

-3.9 ± 3.0

< 0.001

(0.190, 0.001, < 0.001)

CCT (µm)

542.1 ± 29.1

533.3 ± 28.2

532.5 ± 43.3

0.654

IOP at baseline (mmHg)

15.2 ± 3.2

14.6 ± 2.6

15.6 ± 4.3

0.402

VF MD (dB)

0.47 ± 0.9

-5.18 ± 3.1

-5.13 ± 2.8

< 0.001

(< 0.001, < 0.001, 1.000)*

Signal quality score (OCTA)

8.7 (8.4 8.9)

8.4 (8.2 8.6)

8.3 (8.1 8.5)

0.145

Global pRNFLT (µm)

90.3 ± 9.0

72.9 ± 10.2

72.7 ± 8.5

< 0.001

(< 0.001, < 0.001, 0.297)

Affected

hemi-pRNFLT (µm)

116.0 ± 18.0

72.8 ± 14.4

69.8 ± 11.0

< 0.001*

(< 0.001, < 0.001, 0.559)

Unaffected

hemi-pRNFLT (µm)

108.0 ± 17.8

100.0 ± 19.8

96.7 ± 17.2

< 0.001

(0.081, 0.007, 0.639)

Global pVD (%)

50.46 ± 3.6

44.44 ± 5.0

42.62 ± 5.1

< 0.001

(< 0.001, < 0.001, 0.131)

Affected

hemi-pVD (%)

49.49 ± 8.1

41.16 ± 5.8

39.94 ± 6.1

< 0.001

(< 0.001, < 0.001, 0.642)

Unaffected

hemi-pVD (%)

49.42 ± 8.2

47.56 ± 5.4

45.76 ± 5.7

< 0.001

(0.338, 0.017, 0.359)

Global ONH-VD (%)

62.05 ± 6.7

60.38 ± 6.2

56.90 ± 6.3

< 0.001

(0.396, < 0.001, 0.020)

Affected

hemi-ONH-VD (%)

62.79 ± 7.4

59.15 ± 7.7

53.81 ± 9.1

0.001

(0.048, 0.001, 0.032)

Unaffected

hemi-ONH-VD (%)

62.04 ± 6.8

61.94 ± 6.6

57.62 ± 8.4

0.003

(0.997, 0.008, 0.010)

pCVD (%)

74.3 ± 4.4

71.8 ± 5.1

67.1 ± 7.0

< 0.001

(0.031, < 0.001, 0.001)*

Location of (S/I) hemifield loss (%)

 

44/6 (88%)

41/9 (82%)

0.763

Location of (central/peripheral) hemifield loss (%)

 

32/18 (64%)

43/7(86%)

0.12

CMvD presence

 

22/50 (44%)

22/50 (44%)

1.000†

  1. One-way ANOVA test, Tukey HSD as post hoc analysis, * Dunnett T3 test as post hoc analysis
  2. †Chi-square test
  3. Significant P values are shown in bold type
  4. M = male; F = female; SBP = systolic blood pressure; DBP = diastolic blood pressure; MOPP = mean ocular perfusion pressure; AL = axial length; SE = spherical equivalent; CCT = central corneal thickness; IOP = intraocular pressure; VF MD = visual field mean deviation; pRNFLT = peripapillary retinal nerve fiber layer thickness; OCTA = optical coherence tomography angiography; pVD = peripapillary vessel density; pCVD = parapapillary choroidal vessel density; ONH-VD = optic nerve head vessel density; CMvD = choroidal microvasculature dropout; Affected hemi- = perimetrically-affected hemiretinal; Unaffected hemi- = perimetrically-unaffected hemiretinal; S = superior; I = inferior
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BMC Ophthalmology

ISSN: 1471-2415

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