Fig. 3

Ophthalmic features of the proband. (A)Fundus photography showed no abnormality in the bilateral eyes after vitrectomy at first visit and (B)the corresponding FFA shows retinal vessel fluorescence leakage in the peripheral retinal. (C)Fundus photography showed no abnormality in either eye after 9 years, however (D)the corresponding FFA of the bilateral eyes showed peripheral retinal telangiectasia, vascular leakage, and neovascularization. (E)Slit-lamp photography showed iris neovascularization in the bilateral eyes 3 years after last visit and (F)FFA of the bilateral eyes showed a large area of non-perfusion, telangiectasia, vascular leakage, and neovascularization in the posterior pole and peripheral retina. (G)Slit-lamp photography showed resolution of iris neovascularization after panretinal photocoagulation and intravitreal anti-VEGF. Red arrow: abnormal capillaries in the posterior pole and peripheral retina. Black arrow: iris neovascularization